The Korean Journal of Thoracic and Cardiovascular Surgery : eISSN 2093-6516 / pISSN 2233-601X

Fig. 7.

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Fig. 7. SLN resection in mice, pigs, and humans using small-molecule fluorophores. (A) Chemical structures of ICG, ESNF14, and ZW800-3a. (B) 100 nmol (0.1 mL, 1 mg/mL) of ICG solution was injected into the armpit of a mouse 10 minutes prior to imaging and resection. NIR, color, and merged images obtained before and after resection of SLNs []. (C) NIR fluorescence-guided SLN mapping and resection was performed in humans 10–15 minutes after injection of ICG (1–2 mL, 2.5 mg/mL) []. (D) Dual-channel intraoperative NIR imaging of pan lymph nodes and SLN mapping. ESNF14 (5 nmol) was injected intradermally (NIR #1, red) and 320 nmol of ZW800-3a (NIR #2, lime green) was injected intravenously into the same Yorkshire pig 5 minutes and 4 hours before imaging, respectively []. Circle indicates SLN; arrowheads indicate pan lymph nodes. SLN, sentinel lymph node; ICG, indocyanine green; NIR, near-infrared.
Korean Journal of Thoracic and Cardiovascular Surgery 2019;52:205~220 https://doi.org/10.5090/kjtcs.2019.52.4.205
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