Korean Journal of Thoracic and Cardiovascular Surgery 2018; 51(6): 384-389  https://doi.org/10.5090/kjtcs.2018.51.6.384
Preoperative Corticosteroid Use and Early Postoperative Bronchial Anastomotic Complications after Lung Transplantation
Ha Eun Kim, M.D.1, Hyo Chae Paik, M.D.1, Song Yee Kim, M.D.2, Moo Suk Park, M.D.2, and Jin Gu Lee, M.D.1
1Department of Thoracic and Cardiovascular Surgery and 2Division of Pulmonology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine
Corresponding author: Jin Gu Lee, Department of Thoracic and Cardiovascular Surgery, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea
(Tel) 82-2-2228-2140 (Fax) 82-2-393-6012 (E-mail) csjglee@yuhs.ac
Received: June 18, 2018; Revised: September 10, 2018; Accepted: September 11, 2018.; Published online: December 5, 2018.
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Abstract
Background: Airway anastomotic complications are a leading cause of mortality after lung transplantation. Among the factors that cause airway complications, preoperative steroid use has been considered to be related with postoperative airway healing. We analyzed the influence of preoperative steroid use on postoperative airway complications. Methods: The medical records of 66 double-lung transplant recipients from January 2014 to December 2015 were reviewed. Forty patients were prescribed steroids preoperatively. The daily steroid dose was standardized using the patient’s body mass index (BMI). Patients who received preoperative steroids were sub-divided into high-dose (HD) and low-dose (LD) groups (cut-off value, 1.6 mg/BMI/day). Results: Thirteen patients suffered from airway complications postoperatively (bronchopulmonary fistula, 9; bronchial stenosis, 4). There was a tendency for early development of airway complications in the steroid use group compared to the non-steroid use group, but it was not significant (percentage free from airway complications in year 1: non-steroid group, 90.9% vs. steroid group, 79.2%; p=0.43). The percentage of patients in the LD and HD groups who were free from airway complications in year 1 was not significantly different (84.0% vs. 77.8%, p=0.39) Conclusion: The airway complication rate did not vary significantly according to steroid use. Additionally, in patients who received preoperative steroids, the dose did not affect the rate of development of airway complications.
Keywords: Lung transplantation, Preoperative steroid, Airway, Complication


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