Korean J Thorac Cardiovasc Surg 2019; 52(2): 119-123  https://doi.org/10.5090/kjtcs.2019.52.2.119
Lymph Node Metastasis after Spontaneous Regression of Non-Small Cell Lung Cancer
Jae Hwa Jeong , M.D.1, Pil Jo Choi , M.D., Ph.D.1, Jung Hoon Yi , M.D.1, Sang Seok Jeong , M.D.1, Ki Nam Lee , M.D., Ph.D.2
1Department of Thoracic and Cardiovascular Surgery, Dong-A University Hospital, Dong-A University College of Medicine, Busan, Korea; 2Department of Radiology, Dong-A University Hospital, Dong-A University College of Medicine, Busan, Korea
Corresponding author: Pil Jo Choi, Department of Thoracic and Cardiovascular Surgery, Dong-A University Hospital, 26 Daesingongwon-ro, Seo-gu, Busan 49201, Korea,
(Tel) 82-51-240-5195 (Fax) 82-51-231-5195, 82-51-248-1510 (E-mail) pjchoi@dau.ac.kr
Received: September 7, 2018; Revised: October 19, 2018; Accepted: November 1, 2018.; Published online: April 5, 2019.
© The Korean Journal of Thoracic and Cardiovascular Surgery. All rights reserved.

cc This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Spontaneous regression of lung cancer is a very rare and poorly understood phenomenon. A 64-year-old man presented to Dong-A University Hospital with a shrunken nodule in the right lower lobe. Although the nodule showed a high likelihood of malignancy on needle aspiration biopsy, the patient refused surgery. The nodule spontaneously regressed completely in the next 17 months. However, the subcarinal lymph node was found to be enlarged 16 months after complete regression was observed. We pathologically confirmed metastasis of squamous cell carcinoma and performed neoadjuvant chemotherapy, surgery, and adjuvant chemoradiation. Regardless of tumor size reduction, it is preferable to perform surgery aggressively in cases of operable lung cancer.
Keywords: Lung neoplasms, Spontaneous neoplasm regression, Lymphatic metastasis, Surgery


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